The major portion of our research is aimed at elucidating fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded protein within the endoplasmic reticulum (ER). Research into the fundamental processes that regulate protein synthesis and folding within the ER provides key insights for understanding genetic diseases that result from protein folding defects.
Fig. 1. Protein flux through the ER (orange) and principal activities of the UPR to couple the ER protein folding capacity with its protein folding burden (blue). Abbreviations: ER – endoplasmic reticulum, ROS – reactive oxygen species.
(2005) ER stress and the unfolded protein response. Mutat. Res. 569, 29–63
- Schröder M.,
- Kaufman R. J.